July 7, 2007
A University of Toronto study is the first in North America to draw a link between Parkinson's and manganese air pollution, and suggests industry-generated pollutants poses a greater health risk than traffic-generated manganese.
Murray Finkelstein, assistant professor in the department of family and community medicine, worked with Berkeley professor Michael Jerrett to compare the incidence of diagnosis and treatment of Parkinson's with markers of exposure to vehicle exhaust and industrial emissions in the cities of Toronto and Hamilton. The study, which examined a cohort of 110,000 subjects over three years, appeared in Environmental Research 2007.
“The results suggest that the manganese threat posed by traffic-generated pollution may be relatively small, but that exposure to ambient manganese in the air from sources like steel foundries does advance the age of diagnosis of Parkinson's disease,” said Finkelstein. “This study supports the theory that exposure to manganese adds to the natural loss of neurons attributable to the aging process.”
Komatsu F1, Kagawa Y, Kawabata T, Kaneko Y, Chimedregzen U, Purvee B, Otgon J.
A high accumulation of hair minerals in Mongolian people: 2(nd) report; influence of manganese, iron, lead, cadmium and aluminum to oxidative stress, Parkinsonism and arthritis. Curr Aging Sci. 2011 Feb;4(1):42-56.
14 patients with Parkinson Disease (PD) and 14 control patients were randomly selected and examined for cutaneous eruptions and blood mercury levels. Of the 14 PD patients, 13 had Grover's Disease (which results in red, bumpy skin eruptions) and detectable blood mercury levels. None of the patients in the control group had skin eruptions and only 2 had detectable blood mercury levels.
Dantzig PI. A new cutaneous sign of mercury poisoning? J Am Acad Dermatol. 2003;49:1109-1111
Penn Study Finds Link Between Parkinson’s Disease Genes and Manganese Poisoning
Manganism, or manganese poisoning, is prevalent in such occupations as mining, welding, and steel manufacturing. It is caused by exposure to excessive levels of the metal manganese, which attacks the central nervous system, producing motor and dementia symptoms that resemble Parkinson’s disease.