TraceMin: Bisphenol A

Bisphenol A (BPA)

This chemical substance is considered a hazardous chemical. Because it acts like the hormone estrogen, BPA is considered a risk factor for animal and human reproduction and has been associated with reproductive disorders in humans and animals.

Due to processing and recycling of BPA-containing products, the chemical can be detected in water. Because BPA can leach from products, absorption can lead to detection in blood and urine samples.

Bisphenol A in Children's Dentistry

"Dental sealants and composite filling materials containing Bisphenol A (BPA) derivatives are increasingly used in childhood dentistry. Evidence is accumulating that BPA and some BPA derivative can pose health risks attributable to their endocrine-disrupting properties."

Excerpt from article published in Paediatrics 2010.

Analysis

Blood

Needed Material: 3-5ml Whole Blood

Urine

Needed Material: 5-7ml Urine

Saliva

Needed Material: 3ml Saliva

Water

Needed Material: 5-7ml Water

Test in Other Samples

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More Information about BPA

Toxicological and Health Aspects of Bisphenol A

Report of Joint Food and Agriculture Organization of the United Nations (FAO) and World Helath Organization (WHO) - Expert Meeting:

BPA - chemical with adverse affects

Bisphenol A (BPA) can be found in cans, DVDs, thermal paper, baby bottles and food packaging. From these products, the chemical leaches and is absorbed by humans. Through processing and recycling it can pollute rivers and lakes. BPA world production: 3.8 million tons each year.

BPA acts like estrogen and is known to disrupt reproduction in humans and animals. So far, only Canada, Denmark and France have banned the use of BPA in baby bottles and other products for children.

View the press release from the German Environmental Protection Agency (UBA)

Further Limiting Bisphenol A In Food Uses Could Provide Health And Economic Benefits

BPA exposure was estimated to be associated with 12,404 cases of childhood obesity and 33,863 cases of newly incident coronary heart disease, with estimated social costs of $2.98 billion in 2008.

Bisphenol A Impairs Mitochondrial Function in the Liver at Doses below the No Observed Adverse Effect Level

Min Kyong Moon,^1,^*Min Joo Kim,^1,^2,^*In Kyung Jung,^1,²Young Do Koo,¹Hwa Young Ann,^1,²Kwan Jae Lee,²Soon Hee Kim,¹Yeo Cho Yoon,²Bong-Jun Cho,²Kyong Soo Park,¹Hak C. Jang,^1,² and Young Joo Park^1,2

Bisphenol A (BPA) has been reported to possess hepatic toxicity. We investigated the hypothesis that BPA, below the no observed adverse effect level (NOAEL), can induce hepatic damage and mitochondrial dysfunction by increasing oxidative stress in the liver. Two doses of BPA, 0.05 and 1.2 mg/kg body weight/day, were administered intraperitoneally for 5 days to mice. Both treatments impaired the structure of the hepatic mitochondria, although oxygen consumption rate and expression of the respiratory complex decreased only at the higher dose. The hepatic levels of malondialdehyde (MDA), a naturally occurring product of lipid peroxidation, increased, while the expression of glutathione peroxidase 3 (GPx3) decreased, after BPA treatment. The expression levels of proinflammatory cytokines such as interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) also increased. In HepG2 cells, 10 or 100 nM of BPA also decreased the oxygen consumption rate, ATP production, and the mitochondrial membrane potential. In conclusion, doses of BPA below the NOAEL induce mitochondrial dysfunction in the liver, and this is associated with an increase in oxidative stress and inflammation.

BPA Exposure Linked To Asthma In Kids

The list of adverse health effects from BPA exposure continues to grow.

Bisphenol A, or BPA, is commonly used to line food and beverage cans, and helps to keep plastics flexible, but studies suggest the compound can leach into the foods we eat. High levels of BPA in the urine have been tied to behavior problems, obesity, hormone abnormalities and even kidney and heart problems. Now, new research from scientists at the Columbia Center of Children’s Environmental Health is linking the compound to an increased risk for asthma.

How BPA May Disrupt Brain Development

The chemical, found in many plastic products, can interfere with normal brain development.

In a study published in the journal Proceedings of the National Academy of Sciences, researchers report that bisphenol A (BPA) may suppress genes that are critical to early development of the central nervous system, which may predispose both animals and humans to neurodevelopmental disorders.