Balancing Platinum toxicity

• complexation with sulfur-containing compounds inactivates Pt compounds

• (Jones et al 1991)

• Thiosulfate protects against nephrotoxicity

• Glutathion protects against nephrotoxicity, even when high doses of cisplatin are administered

• Byrostatin downregulates protein kinase C and sensitizes cells to cisplatin

• Nucleoside transport inhibitor dipyridamole enhances platinum toxicity

• Clavert, Judson, van der Vijgh, Platinum complexes in cancer medicine. In Pharmacokinetics and Cancer Chemotherapy. Cold Spring Harbor Laboratories 1993

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